We have recently found using a relatively new technique called microarrays that primary EBV infection induces a reproducible alteration in the gene expression profile of blood cells. To find out if this gene expression profile is specific for EBV versus being shared with other viral infections, we have started to examine the pattern evoked by influenza immunization of some of our Mono 5 subjects who have not been infected by EBV and some who have. If the pattern is not seen among the subjects who have not been infected but is found in the subjects who have been infected, this would be evidence that it is specific for EBV infection. If it is not seen in either group, this would be evidence that it is specific for primary EBV infection. In other words, when this virus infects us, does it leave a calling card with our immune system?
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